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Fully automated dual-color dual-hapten silver in situ hybridization staining for MYC amplification: a diagnostic tool for discriminating secondary angiosarcoma.

Identifieur interne : 002A70 ( Main/Exploration ); précédent : 002A69; suivant : 002A71

Fully automated dual-color dual-hapten silver in situ hybridization staining for MYC amplification: a diagnostic tool for discriminating secondary angiosarcoma.

Auteurs : Jennifer S. Ko [États-Unis] ; Steven D. Billings ; Christopher P. Lanigan ; Darya Buehler ; Anthony P. Fernandez ; Raymond R. Tubbs

Source :

RBID : pubmed:24329959

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English descriptors

Abstract

MYC amplification occurs in post-radiation and chronic lymphedema-associated secondary angiosarcoma and some primary angiosarcomas. In this study, we tested the ability of automated dual-color dual-hapten in situ hybridization (DISH) staining to discriminate secondary angiosarcoma from radiation-associated atypical vascular lesions (AVL), and to correlate with fluorescence in situ hybridization (FISH) for MYC amplification.

DOI: 10.1111/cup.12278
PubMed: 24329959


Affiliations:


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Le document en format XML

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<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Gene Amplification</term>
<term>Hemangiosarcoma (genetics)</term>
<term>Hemangiosarcoma (metabolism)</term>
<term>Hemangiosarcoma (pathology)</term>
<term>Humans</term>
<term>In Situ Hybridization (methods)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neoplasms, Radiation-Induced (genetics)</term>
<term>Neoplasms, Radiation-Induced (metabolism)</term>
<term>Neoplasms, Radiation-Induced (pathology)</term>
<term>Proto-Oncogene Proteins c-myc (genetics)</term>
<term>Proto-Oncogene Proteins c-myc (metabolism)</term>
<term>Retrospective Studies</term>
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<term>Femelle</term>
<term>Humains</term>
<term>Hybridation in situ ()</term>
<term>Hémangiosarcome (anatomopathologie)</term>
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<term>Sujet âgé</term>
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<term>Tumeurs cutanées (génétique)</term>
<term>Tumeurs cutanées (métabolisme)</term>
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<term>Hémangiosarcome</term>
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<term>Hybridation in situ</term>
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<div type="abstract" xml:lang="en">MYC amplification occurs in post-radiation and chronic lymphedema-associated secondary angiosarcoma and some primary angiosarcomas. In this study, we tested the ability of automated dual-color dual-hapten in situ hybridization (DISH) staining to discriminate secondary angiosarcoma from radiation-associated atypical vascular lesions (AVL), and to correlate with fluorescence in situ hybridization (FISH) for MYC amplification.</div>
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